Minyak atsiri sereh ( Cymbopogon ci

Minyak atsiri sereh ( Cymbopogon citratus) terbukti memiliki khasiat sebagai antibakteri terhadap bakteri patogen, seperti Staphylococcus aureus. Minyak atsiri dari sereh diformulasikan dalam bentuk sediaan gel dengan kombinasi basis HPMC dan karbopol. Penggunaan kombinasi ini diketahui akan menghasilkan gel dengan sifat fisik yang lebih baik daripada penggunaan tunggal. Penelitian ini bertujuan untuk meneliti pengaruh variasi HPMC dan karbopol terhadap sifat fisik gel, konsentrasi HPMC dan karbopol untuk menghasilkan formula optimum, dan stabilitas fisik gel minyak atsiri sereh selama penyimpanan.
Sediaan gel dibuat dengan kadar minyak atsiri sereh 6% dengan basis HPMC dan karbopol. Masing-masing formula dibuat dan dilakukan uji sifat fisik yang meliputi organoleptis, homogenitas, pH, daya sebar dan daya lekat. Komposisi HPMC dan karbopol ditentukan melalui proses skrining dan optimasi menggunakan metode Simplex Lattice Design dengan perangkat lunak Design Expert 7.1.5. Hasil percobaan dan prediksi SLD diverifikasi dengan uji one sample t-test dengan taraf kepercayaan 95%.
Formula optimum gel minyak atsiri sereh terdiri dari 4,00% HPMC dan 1,00% karbopol. Hasil uji sifat fisik gel minyak atsiri sereh diperoleh gel yang homogen dengan nilai pH 6,00 ± 0,00, viskositas 280,00 ± 26,46 dPa.S, daya sebar 9,36 ± 0,47 cm2, dan daya lekat 2,36 ± 0,10 detik. Stabilitas fisik diuji dengan metode cycling test selama 3 siklus dan dianalisis secara statistik menggunakan one-way ANOVA taraf kepercayaan 95% yang menggambarkan stabilitas gel minyak atsiri sereh. Gel minyak atsiri sereh stabil selama 3 siklus pengujian meliputi organoleptis, homogenitas, sineresis, pH, daya lekat, dan viskositas kecuali daya sebar gel yang tidak stabil.
Kata kunci : Gel, sereh, HPMC, karbopol

Hasil (Inggris) 2:

Essential oils of lemongrass (Cymbopogon citratus) is shown to have antibacterial efficacy against pathogenic bacteria, such as Staphylococcus aureus. Essential oils of citronella gel formulated into dosage forms with a combination of HPMC and carbopol base. The use of this combination is known to produce a gel with physical properties better than a single use. This study aimed to investigate the effect of variations of HPMC and carbopol to the physical properties of the gel, the concentration of HPMC and carbopol to produce the optimum formula, and physical stability gel essential oil of citronella during storage.
The preparation gel is made ​​with high levels of essential oil of citronella 6% HPMC base and carbopol. Each formula were made ​​and tested the physical properties that include organoleptic, homogeneity, pH, dispersive power and adhesion. HPMC and carbopol composition is determined through the process of screening and optimization methods Simplex Lattice Design by Design Expert 7.1.5 software. SLD experimental results and predictions verified by testing one sample t-test with a 95% confidence level.
Formula optimum gel lemongrass essential oil consists of 4.00% and 1.00% HPMC carbopol. The test results of physical properties of essential oil of citronella gel obtained homogeneous gel with a pH value of 6.00 ± 0.00, 280.00 ± 26.46 dPa.S viscosity, dispersive power of 9.36 ± 0.47 cm 2, and adhesion 2 , 36 ± 0.10 seconds. Physical stability was tested by the method of cycling test for 3 cycles and statistically analyzed using one-way ANOVA level of 95% which illustrates the stability of the gel lemongrass essential oil. Gel citronella essential oil is stable for 3 cycles of testing include organoleptic, homogeneity, syneresis, pH, adhesion, and the viscosity of the gel unless the dispersive power is not stable.
Keywords: gel, lemongrass, HPMC, carbopol