Viral infections hepatitis B (HBV) is a serious world health problems, this is evident with ditemukanya cases in Africa and Asia that still remains a major cause of morbidity and mortalitas1. Each year, more than 1.2 million people die of HBV infected with chronic infection, cirrhosis and hepatoseluler karsinoma2. In Negeria although already enacted granting vaccine effectively but still declared the region with an estimated prevalence of HBV hiperendemik 12% 3 and still continue to be reported with an estimated prevalence will increase every year.
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