klindamisin fosfat merupakan antibi

klindamisin fosfat merupakan antibiotik yang digunakan sebagai anti jerawat untuk pengobatan infeksi yang disebabkan oleh bakteri anaerob baik secara oral maupun topikal di kulit, karena berperan dalam proses penghambatan pertumbuhan bakteri penyebab jerawat Propionibacterium acnes. Klindamisin fosfat dibuat dalam konsentrasi 1% sebagai anti jerawat. Pada penelitian ini dibuat sebanyak 4 formula nanopartikel dengan konsentrasi polimer sitrat dan kitosan yang bervariasi, yaitu formula I dengan sitrat 0,1% dan kitosan 0,1%, formula II dengan sitrat 0,2% dan kitosan 0,1%, formula III dengan sitrat 0,1% dan kitosan 0,2%, serta formula IV dengan sitrat 0,2% dan kitosan 0,2%. Nanopartikel dibuat dengan metode gelasi inonik caranya mencampurkan sitrat yang polianionik ke dalam kitosan yang polikationik setetes demi tetes menggunakan magnetic stirer. Hasil uji ukuran partikel diperoleh ukuran partikel formula II sebesar 92.1 nm. Nanopartikel yang terbentuk lalu dilakukan uji penjeratan dan pelepasan zat aktif. Dari hasil uji penjeratan dan pelepasan zat aktif diperoleh bahwa nanopartikel formula II yang terbaik karena memiliki penjeratan 81,88%. Nanopartikel formula II yang terbentuk diformulasikan menjadi sediaan gel yang akan diuji dengan evaluasi meliputi uji homogenitas, uji viskositas dan sifat alir, uji daya sebar, dan uji pH. Dari hasil uji evaluasi diperoleh bahwa gel nanopartikel stabil pada suhu kamar dengan organoleptik homogen, bau khas dan berwarna bening transparan, viskositas 245000-550000 cps yang diukur pada 3 rpm, kemampuan daya sebar 58,55-61,25 mm, pH 5,87. Hasil uji aktivitas antiacne terhadap sediaan gel mengandung 1% klindamisin nanopartikel memiliki daya hambat sebesar 29,5 mm yang dibandingkan dengan produk Medi-klin memiliki daya hambat sebesar 23,5 mm.

Hasil (Inggris) 1:

clindamycin phosphate is an antibiotic that is used as an acne treatment for infections caused by anaerobic bacteria either orally or topically on the skin, because it plays a role in the process of the inhibition of the growth of bacteria causes acne is Propionibacterium acnes. Clindamycin phosphate is made in a concentration of 1% as anti acne. On the research made by as much as 4 nanoparticles with a concentration formula citric and Chitosan polymer varied, that formula I with citrate 0.1% and Chitosan 0.1%, formula II with citrate 0.2% and 0,1% Chitosan, formula III with citrate 0.1% and 0,2% Chitosan, as well as citrate formula IV with 0.2% and 0.2% Chitosan. Nanoparticles made with the method of citric mix gelasi inonik way that polianionik into a polikationik a drop of Chitosan for the sake drops using magnetic stirer. The results of a test particle size particle size is obtained the formula II amounted to 57.2 nm. Nanoparticles are formed and then performed a test of penjeratan and release of active substances. From the results of the test penjeratan and release of active substances obtained that nanoparticles formula II is best because it has a penjeratan 81,88%. Formula II nanoparticles formed formulated gel preparations that will be tested with the test include evaluation of its homogeneity, test the viscosity and flow properties, test the power spread, and test the pH. Evaluation of the test results obtained from that stable nanoparticle gels at room temperature with a homogeneous organoleptik, peculiar smell and a clear-colored transparent viscosity cps 245000-550000 people measured at 3 rpm, power capabilities spread 58,55-61,25 mm, pH 5.87. The results of the assay activity antiacne preparations against the gel contains 1% clindamycin nanoparticles have a drag of 29.5 mm compared with a product Medi-klin has drag power amounted to 23.5 mm.

Hasil (Inggris) 2:

clindamycin phosphate is an antibiotic that is used as an anti-acne for the treatment of infections caused by anaerobic bacteria orally or topically on the skin, because it plays a role in the inhibition of the growth of acne-causing bacteria Propionibacterium acnes. Clindamycin phosphate is made in a concentration of 1% as anti-acne. In this study is made by 4 formula nanoparticles with a polymer concentration of citrate and chitosan varied, ie formula I with citric 0.1% and 0.1% chitosan, citric formula II with 0.2% and 0.1% chitosan, formula III with citric 0.1% and 0.2% chitosan and citrate formula IV with 0.2% and 0.2% chitosan. The nanoparticles prepared by the method of mixing the gelation inonik citrate polianionik way into the polycationic chitosan drop by drop using a magnetic stirrer. The test results obtained particle size particle size of 92.1 nm formula II. The nanoparticles are formed and then test entrapment and release of active substances. From the test results entrapment and release of active substances was found that nanoparticles of formula II is best because it has a 81.88% entrapment. Formula II formed nanoparticles formulated into a gel formulation will be tested by the evaluation include homogeneity, viscosity and flow properties test, test dispersive power, and a pH test. Evaluation of the test results showed that the gel nanoparticles are stable at room temperature with homogeneous organoleptic, distinctive smell and colorless clear transparent, 245000-550000 cps viscosity measured at 3 rpm, dispersive power capability from 58.55 to 61.25 mm, pH 5.87 , The test results on the preparation antiacne activity containing 1% clindamycin gel nanoparticles have inhibitory 29.5 mm compared with Medi-Klin products have inhibitory of 23.5 mm.