Three distinct stages of translatio

Three distinct stages of translation
Initiation
•Rate limiting step
•Requires hydrolysis of ATP and GTP
•Results in formation of a complex containing the mRNA, the ribosome and the initiator Met-tRNA
A. 5’ end (Cap) dependent initiation
• The initiation complex binds to the 5’ cap structure and scans in a 5’ to 3’ direction until initiating AUG is encountered
B. Internal ribosome entry
Initiation complex binds upstream of initiation codon

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Three distinct stages of translation Initiation • Rate limiting step • Requires hydrolysis of ATP and GTP • Results in formation of a complex containing the mRNA, the ribosome and the initiator Met-tRNA A. 5 ' end (Cap) dependent initiation• The initiation complex binds to the 5 ' cap structure and scans in a 5 ' to 3 ' Ene until initiating AUG is encounteredB. Internal ribosome entry Initiation complex binds upstream of the initiation codon

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