Ranitidin HCl merupakan obat yang b

Ranitidin HCl merupakan obat yang bekerja pada histamin dan secara selektif menghambat reseptor antagonis H2, ranitidin HCl digunakan untuk mengobati ulkus lambung dan duodenum, penyakit gastroesophageal reflux ( GERD ), dan sindrom Zollinger – Ellison. Bioavaibilitas dari ranitidine HCl sekitar 50% setelah pemberian oral dengan waktu paruh 2-3 jam. Salah satu sisitem penghantaran obat yang dapat meningkatkan nilai bioavaibilitas ranitidin HCl yaitu mucoadhesif. Tujuan dari penelitian ini yaitu Mengetahui pengaruh pengaruh HPMC K100M, terhadap sifat fisik dan pelepasan zat aktif dari sediaan granul mucoadhesif dan mendapatkan formula yang opotimum untuk garnul mucoadhesif ranitidin HCl. Metode yang digunakan dalam pembutan garanul mucoadhesive ranitidin HCl yaitu granulasi basah. Dalam pembutan formula garnul mucoadhesif ranitidine HCl dibuat dalam 4 formulasi dengan variasi kadar polimer (HPMC K100M) secara berturut-turut 0 mg, 70 mg, 80 mg, dan 100 mg. Evaluasi hasil dari granul mucoadhesif ranitidin HCl yaitu uji distribusi ukuran partikel, laju alir, uji kadar air, daya mengembang, uji bioadhesi in vitro dan uji wash off. Analisa hasil data yang diperoleh dianalisis dengan pendekatan teoritis dan pendekatan statistik. Pendekatan teoritis membandingkan nilai dari hasil penelitian dengan teori yang ada pada literature. Dan pendekatan statistik menggunakan uji ANOVA, dimana untuk mengetahui adanya perbedaan bermakna dari masing-masing uji.

Hasil (Inggris) 1:

Ranitidine HCl is a drug that works on histamine and selectively inhibits the receptor antagonists H2, ranitidine HCl is used to treat ulcers of the stomach and duodenum, gastroesophageal reflux disease (GERD) and Zollinger Ellison syndrome –. Bioavaibilitas of ranitidine HCl approximately 50% after administering oral with a half-life of 2-3 hours. One of sisitem medications which can increase transfers value bioavaibilitas ranitidine HCl i.e. mucoadhesif. The goal of the research is to know how the influence of HPMC K100M, against the physical properties and release of active substances from mucoadhesif granule preparation and get a opotimum formula for garnul mucoadhesif ranitidine HCl. Methods used in pembutan garanul mucoadhesive ranitidine HCl that is wet granulation. In the pembutan formula garnul mucoadhesif ranitidine HCl is made in 4 formulations with variations in the levels of polymers (HPMC K100M) respectively 0 mg, 70 mg, 80 mg, and 100 mg. Evaluation of the results of granule mucoadhesif ranitidine HCl i.e. particle size distribution test, flow rate, water content, test power expands, in vitro bioadhesi test and test wash off. Analysis of the results of the data obtained were analyzed with the statistical approach and theoretical approach. Theoretical approach of comparing the value of research results with existing theory on literature. And statistical approach using ANOVA test, where the presence of meaningful differences for each test.

Hasil (Inggris) 2:

Ranitidine HCl is a drug that works on selectively inhibits histamine and H2 receptor antagonists, ranitidine HCl is used to treat gastric and duodenal ulcers, gastroesophageal reflux disease (GERD), and the syndrome Zollinger - Ellison. Ranitidine HCl bioavailability of approximately 50% after oral administration with a half-life of 2-3 hours. One sisitem drug that can enhance the bioavailability of ranitidine HCl value is mucoadhesif. The purpose of this research is to know the effect the effect of HPMC K100M, the physical properties and the release of active substances of the preparation of granules mucoadhesif and get the formula for garnul mucoadhesif opotimum ranitidine HCl. The method used in pembutan garanul mucoadhesive ranitidine HCl is wet granulation. In the formula pembutan garnul mucoadhesif ranitidine HCl made in 4 formulations with variations in the levels of polymer (HPMC K100M), respectively 0 mg, 70 mg, 80 mg, and 100 mg. Evaluation of the results of ranitidine HCl granules mucoadhesif is test particle size distribution, flow rate, moisture content test, power expands, bioadhesi test in vitro and wash off test. Analysis of the results of the data obtained were analyzed with the theoretical approaches and statistical approaches. The theoretical approach to compare the value of the research results with the existing theories in literature. And statistical approach using ANOVA test, where to find any significant differences from each test.