Akar kuning (Arcangelisia flava (L)

Akar kuning (Arcangelisia flava (L) Merr) merupakan tanaman herbal yang diketahui sebagai agen hepatoprotektor. Tujuan dari penelitian ini adalah untuk mengetahui kemampuan ekstrak etanol akar kuning (Arcangelisia flava (L) Merr) dalam menurunkan aktivitas enzim alkaline phosphatase (ALP) dan bilirubin.
Penelitian bersifat eksperimental dengan rancangan post test only control group design. Penelitian ini menggunakan tikus putih jantan galur wistar sebanyak 30 ekor yang terbagi dalam 6 kelompok. Kelompok I, sebagai perlakuan kelompok normal yang tidak diberikan perlakuan apapun, Kelompok II (kontrol) hewan uji diberi CCl4 dosis 0,5mL/kgBB (i.p), Kelompok III IV,V : hewan uji diberi etanol akar kuning dengan dosis 100 mg/kgBB, 250 mg/kgBB, 500 mg/kgBB dan CCl4 dosis 0,5mL/kgBB(i.p). Kelompok VI : hewan uji diberi suspensi standar curcumin dosis 300 mg/kgBB dan CCl4 dosis 0,5mL/kgBB . Darah diambil melalui sinus orbitalis untuk diuji aktivitas enzim Alkaline phosphatase (ALP) dan bilirubin. Aktivitas enzim alkaline phosphatase (ALP) dan bilirubin kemudian diuji statistik
Hasil penelitian menunjukkan bahwa kadar ALP dari pemberian ekstrak etanol akar kuning (Arcangelisia flava (L) Merr) dengan dosis 125, 250 dan 500 mg/ kgBB, Curcumin, dan kontrol berturut-turut 65.34 ± 0.76 U/L, 60.65 ± 1.95 U/L, 53.21 ± 1.57 U/L, 46.04 ± 2.50 U/L, 86.29 ± 0.01 U/L dan kadar bilirubin dari pemberian ekstrak etanol akar kuning (Arcangelisia flava (L) Merr) dengan dosis 125, 250 dan 500 mg/ kgBB, curcumin, dan kontrol berturut-turut 1.35 ± 0.12mg/dL, 0.97 ± 0.08 mg/dL, 0.68 ± 0.08 mg/dL, 0.50 ± 0.08 mg/dL, dan 1.94 ± 0.19 mg/dL.
Kesimpulan dari hasil penelitian menunjukan bahwa ekstrak etanol akar kuning (Arcangelisia flava (L) Merr) dapat menurunkan kadar ALP dan bilirubin.

Hasil (Inggris) 2:

Yellow root (Arcangelisia flava (L) Merr) is an herbal plant known as a hepatoprotective agent. The aim of this study was to determine the ability of ethanol extract yellow root (Arcangelisia flava (L) Merr) in lowering the activity of the enzyme alkaline phosphatase (ALP) and bilirubin.
Research is experimental design with post test only control group design. This study used male rats wistar strain as many as 30 individuals were divided into 6 groups. Group I, as a normal treatment group were not given any treatment, group II (control) the test animals were given a dose CCl4 0,5ml / kg (ip), group III IV V: test animals were given ethanol a yellow root with a dose of 100 mg / kg , 250 mg / kg, 500 mg / kg and CCl4 dose of 0,5ml / kg (ip). Group VI: standard suspension test animals were given curcumin dose of 300 mg / kg and CCl4 dose of 0,5ml / kg. Blood is collected through orbital sinus for testing the activity of the enzyme alkaline phosphatase (ALP) and bilirubin. The activity of the enzyme alkaline phosphatase (ALP) and bilirubin then statistically tested
results showed that levels of ALP from the ethanol extract of the roots of the yellow (Arcangelisia flava (L) Merr) at a dose of 125, 250 and 500 mg / kg, Curcumin, and controls respectively 65.34 ± 0.76 U / L, 60.65 ± 1.95 U / L, 53.21 ± 1:57 U / L, 46.04 ± 2:50 U / L, 86.29 ± 0:01 U / L and bilirubin levels of ethanol extract of the roots of the yellow (Arcangelisia flava (L) Merr ) at a dose of 125, 250 and 500 mg / kg, curcumin, and controls successively 1:35 ± 0.12mg / dL, 0:08 ± 0.97 mg / dL, 0:08 ± 0.68 mg / dL, 0:50 ± 0:08 mg / dL, and 1.94 ± 0:19 mg / dL.
The conclusion of the research results showed that the ethanol extract of the roots of the yellow (Arcangelisia flava (L) Merr) can reduce levels of ALP and bilirubin.